All-natural PriaPlex® Hair Support Formula is an herbal supplement designed to halt age-related hair loss while promoting fuller, thicker hair growth in both men and women.
The U.S. Patented herbal formula supports healthy hair from “the inside out” with an advanced blend of “essence tonic” botanicals that aid in restoring circulation to the follicles. In addition to reducing excessive hair loss and restoring fuller hair growth, users of PriaPlex often report on improved skin tone, energy and overall health.
Healthy Follicles for Healthy Hair
Human hairs are produced by follicles, among the most active and fastest growing structures in the body. Follicles are specialized organs that cover the entire body, with the exception of the palms and soles of the feet. Follicles are composed of three major structures – the dermal papilla, hair matrix, and hair shaft. (Fig. 1. above)
The dermal papilla, a pear-shaped structure located at the base of the hair follicle, is comprised of connective tissues and a capillary loop containing tiny blood vessels that provide the nutrients required for hair growth.
The papilla is surrounded by the “matrix” – a bulb-shaped collection of specialized epithelial cells that produce a protein, keratin, that actually forms the hair fiber. The matrix also contains melanocytes, specialized pigment cells that infuse the growing hair shaft with melanin, the compound that gives otherwise transparent hair its natural coloring. Different types of melanin produce different colors – yellow, rust, brown, and black – that combine to produce a wide variety of hair colors, ranging from blond to brown to pitch-black. Red hair is the result of another type of coloring agent, the iron-containing pigment called trichosiderin.
Three Stages of Hair Growth
Mature human hair growth occurs in three distinct phases – growth, transition and rest – that are collectively referred to as the hair cycle (Fig. 2).
1. Growth Phase (Anagen): Each hair cycle begins with a growth (anagen) phase. This is marked by rapid cell division in the hair matrix that builds up layers of keratin to form a single hair shaft that grows out from the follicle at a rate of up to one inch per month. This growth phase typically lasts two to six years. At any given time, about ninety percent of all scalp hairs are in the active growing phase.
2. Transitional Phase (Catagen): At the end of the anagen phase, hair growth ceases and the follicle enters the transition (or catagen) phase. During this phase hair matrix cells begin to die off as the follicle base and bulb begin to shrink. Over time, this shrinkage (miniaturization) pinches off the lower hair bulb, cutting off access to the blood vessels and circulation necessary for hair growth. At any given time, one to two percent of all hair follicles are in this transition phase, which lasts one to two weeks.
3. Resting Phase (Telogen): The final stage of the hair cycle is the resting (or telogen) phase. During this phase, the mature hairs reside in the follicle for five to six weeks before falling out. Approximately 10 percent of all hairs are in this transition period at any given time, accounting for normal shedding of between thirty and fifty hairs each day.
After shedding the hair shaft, the follicle begins a new cycle of hair growth, marked by the swelling of the dermal papilla and the formation of a new capillary loop. As blood vessels reattach to the papilla, they grow and expand four-fold to provide the hair matrix with the nutrients necessary for growing new hair.
The entire process – growth, transition and rest – makes up one complete hair cycle. Each hair follicle is limited to the number of hair cycles that can be completed – estimated to be between 20 and 25 cycles – before reverting to vellus hairs (peach fuzz) and eventually disappearing.
Human Aging and Hair Appearance
In humans, the hair-growing (anagen) phase is at its longest – ranging up to seven years – and the transition/resting phases are at their shortest – lasting only about four months – throughout youth and adolescence. As a result of the great amount of time devoted to supporting hair growth in adolescence, hair is at its healthiest and most attractive throughout this phase of life.
Beginning at around age 35, changes in hair cycles begin to affect the density and overall appearance of hair. With each successive cycle, the amount of time spent in the growing phase is reduced, resulting in shorter, thinner hairs. Additionally, the amount of time spent in the resting phase lengthens, extending the period between when a hair falls out and when a new one grows back. The result of these changes is a gradual reduction in overall hair density and appearance.
Changes in hair color also begin to appear, as pigment-producing melanocytes gradually die out, causing hairs to slowly turn gray.
Excessive Hair Loss
While gradual hair loss is a normal part of human aging, for many people excessive hair loss, or balding, is a significant source of anxiety. Based on several characteristics, hair loss can be roughly divided into two categories – temporary and permanent. Temporary hair loss, which is usually caused by excessive stress, poor diet, hormonal imbalance and endocrine dysfunction, can often be restored within six months to two years after eliminating the underlying cause(s). Permanent hair loss is caused by genetics and is considered irreversible.
Medical Options for Hair Loss
An ideal solution for hair loss would be one that 1) promotes new hair growth while extending the anagen (growing) phase, 2) lengthens the catagen (transitional) phase, and 3) shortens the telogen (resting) phase.
The two most widely used medical treatments for androgenic alopecia – Propecia® and Rogaine® – offer partial solutions by addressing hair loss in two completely different ways. Propecia primarily works to halt hair loss by blocking the production of the follicle-damaging hormone, DHT, while Rogaine aims to support hair growth by increasing blood flow to the hair roots.
Option 1: Block Production of DHT
Propecia (Finasteride), is an oral prescription drug from Merck & Co. that was first marketed as Proscar® for the treatment of enlarged prostate (benign prostatic hyperplasia or BPH). Overabundance of DHT has been established as a contributing factor in the development of BPH and prostate cancer. Proscar (5 mg finasteride) has been shown to effectively lower DHT levels by preventing the enzyme, 5-alpha-reductase, from converting testosterone into DHT. Soon after Proscar was approved, Merck researchers noted that men taking finasteride were showing signs of hair regrowth. This led Merck to begin testing a lower dose of the drug finasteride as a potential treatment for hair loss, and in 1997 the FDA approved Propecia™ (finasteride 1 mg) for the treatment of androgenic alopecia in men.
Following its introduction, Propecia was shown to be highly effective at decreasing DHT concentrations in the blood (by up to 70%), and the scalp (by up to 60%) to reverse DHT-related hair loss of the vertex (at top of head) and anterior mid-scalp area. Unfortunately, there were some serious side effects.
In addition to being present in hair follicles, 5-alpha-reductase is also abundant in the prostate and seminal vesicles, where it plays a vital role in the healthy development and maintenance of normal physiological functions. Reduction of DHT in these organs has now been linked to unwanted side effects in men, including decreased libido, sexual dysfunction, and a reduction of mature sperm count. Additionally, women cannot use Propecia, and Merck explicitly warns women who are or may be pregnant not to even handle crushed or broken Propecia tablets, since the active ingredient may cause abnormalities of a male baby’s sex organs.
Option 2: Stimulate Blood Flow to Follicles
Minoxidil (Rogaine) was originally developed as an oral drug for the treatment of hypertension, based on its ability to relax vascular smooth muscles and produce peripheral vasodilation. By directly stimulating circulation to the hair follicles, Minoxidil was found to extend hair and redirect resting hair follicles into new growth.
Animal experiments have shown that Minoxidil works, in part, by increasing vascular endothelial growth factor (VEGF) to promote hair growth and reactivate dormant hair follicles. However, when taken orally to restore hair, minoxidil was also found to have a number of side effects, including unwanted hair growth in women (hirsutism). Most of these side effects were averted by the introduction of a topical form of Rogaine for use as an external-use hair-restorer in 1988.
Clinical literature shows that Minoxidil performs excellently in preventing hair loss (80%), but less than 20% of patients with androgenetic alopecia experience actual hair growth. Clinical observations indicate that the effects of Minoxidil can be seen within 6-12 months of continual use. Yet once treatment has stopped, within three months all hair growth effects disappear and revert back to the untreated state.
A New Option for Healthy Hair
In Traditional Chinese Medicine (TCM), conditions such as hair loss are addressed by balancing both the “surface” and “root” levels of the problem. Now, after ten years of intensive research, development, and clinical evaluation, a patented, all-natural herbal TCM supplement is available in the United States to aid in halting age-related hair loss while promoting healthy hair growth.* By promoting healthy circulation in the tiniest blood vessels (microcapillaries) that supply nutrients and oxygen to the hair follicles, the formula supports thicker, healthier hair, improved skin tone and overall health and vitality.*
Natural Herbal Support for Age-Related Hair Loss
While losing 30 to 40 hairs per day is considered normal, shedding more than 100 hairs per day is considered excessive and may be a sign of age-related hair loss. Age-related hair loss affects roughly 40 million men in the US. In fact, an estimated 25 percent of men notice the first signs of age-related hair loss as early as 30 years of age, and up to 66 percent will experience significant effects by age 60.
Age-related hair loss isn’t exclusively a male issue — approximately 50 percent of all women over the age of 50 experience a similar condition. Age-related hair loss is generally less severe for women, appearing as an overall thinning of hairs across the top of the head, and the gradual loss of hair down the center part-line of the scalp.
In Traditional Chinese Medicine (TCM), age-related hair loss is considered a condition that is best addressed with a two-pronged approach to balance both the “surface” and “root” levels of the issue. In this case, the “surface” level is the hair and scalp, and the “root” level refers to general body health and constitution.
PriaPlex Advanced Herbal Formula
After 10 years of intensive research, development and clinical evaluation, PriaPlex® herbal hair support formula is now available in the United States. PriaPlex is a patented, all-natural herbal supplement that has been shown to aid in addressing age-related hair loss while promoting healthy hair growth, improved skin texture, and enhanced energy and vitality in men and women.*
PriaPlex addresses hair health from the inside out by combining essence herbs traditionally used to reduce excessive hair loss with a nourishing blend of botanicals shown to help support circulation to nourish the skin and follicles.*
By promoting healthy circulation in the tiniest blood vessels (microcapillaries) that supply nutrients and oxygen to the hair follicles, PriaPlex supports thicker, healthier hair, improved skin tone and overall health and vitality.*
In a recent randomized, double-blind, placebo-controlled study, 52.9% of male and female subjects with age-related hair loss reported significantly thicker hair after taking PriaPlex for only six months, versus 13% of subjects receiving a placebo.
Based on years of clinical evaluation, men and women can realistically expect to see signs of healthier hair in 3 to 6 months, with gradual and continued improvements over the following 12 to 18 months.
Men and women taking PriaPlex for hair loss have reported the following observations:
- At 5-10 days, energy, strength, and stamina improved.*
- At 3-4 weeks, facial skin tone and color appear healthier.*
- At 6-12 weeks, excessive hair loss slows down and/or stops.*
- At 3-6 months, hair appears healthier and thicker.*
Note: PriaPlex is not effective for hair loss in areas where shiny skin indicates that the follicles have miniaturized to the point where they are permanently lost.
* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.