Modifying hair follicle growth cycles is a complicated matter. Researchers have identified several growth factors and hormones involved in hair proliferation and growth. For example, Fibroblast Growth Factor 3 (FGF-3) and Fibroblast Growth Factor 5 (FGF-5) aid in shifting follicles from hair growth to follicle degradation.
Conversely, Insulin-like Growth Factor (IGF-1) and Fibroblast Growth Factor 7 (FGF-7) have been shown to support hair growth by lengthening the telogen (growth) phase of hair follicles. Additionally, Vascular Endothelial Growth Factor (VEGF), Hepatocyte Growth Factor (HGF) and Endothelial Cell Growth Factor (EGF) aid in extending the hair growth period.
Currently, these growth factors and hormones are useful for filtering hair growth regulators and interpreting their mechanism of action. Given the gap between basic research (in vitro) and clinical applications (oral), current treatments are limited to topical hair growth products.
Saw palmetto extract, for example, has been shown to inhibit 5α-reductase in vivo, but has no effect when taken orally, which is why it is commonly used in topical hair products. Adenosine, which has been shown to enhance FGF-7 levels in hair follicles, is another popular ingredient for topical hair tonics. And several plant extracts are commonly added to hair creams to block the effects of FGF-5.
Nevertheless, these treatments are limited to targeting “surface” issues, bypassing deeper “root” issues contributing to hair loss.
PriaPlex Shown to Support Hair Growth Factors
Studies with PriaPlex have found that the enhanced levels of Vascular Endothelial Growth Factor (Fig. 1) and Hepatocyte Growth Factor (Fig. 2) in hair follicles. Additionally, PriaPlex was shown to increase the number of active hair follicles (Fig. 3), while promoting faster growth and increased length of individual hairs (Fig. 20, next page).
Additional Health Benefits
In addition to halting hair loss and increasing hair growth, PriaPlex has been shown to benefit overall health.* Subjects reported increased levels of vitality and energy after 1 to 2 weeks, and improved skin tone and complexion after 6 to 8 weeks.* Additional tests have revealed that the formula exerts anti-fatigue and liver-protective functions, and in vitro trials have identified significant antioxidant activity and anti-aging benefits.
Limitations of Most Common Hair Products
To date only 64 U.S. patents have been granted for inventions addressing human hair issues. Of these, 59 are for products limited exclusively to external (topical) use only. And while the remaining five patents cover products intended for internal use, they contain active ingredients that are not recommended for long term use. Significantly, the PriaPlex proprietary formula, B401, is the only oral, medicinal herbal formulation ever granted a U.S. patent for reducing hair loss and supporting healthy hair growth. Most importantly, because the patent covers commonly used herbal ingredients, the formulation is safe for long term use.
PriaPlex Patents Approved in U.S., Asia and Europe
After years of development, the PriaPlex was released as a new food-based formulation in 2008. In 2010, patents were approved in the United States (Patent Number: U.S. 7,838,048 subject: Medical herb composition for inhibiting shedding of a mammal’s hair and method for preparing the same) and Taiwan (Patent Number I 329 491. Title: Chinese medicine composition for hair loss reduction and its preparation method). According to the Intellectual Property Office of Taiwan, this is the first, and only, patent ever granted for a hair-loss formula. Patents have also been approved in Germany and China, with additional applications pending globally.
PriaPlex has been shown to support hair health by combining specific “essence tonic” herbs that have traditionally been used to reduce excessive hair loss, with additional botanical ingredients known to enhance circulation to the skin and scalp.* The result is a unique, patented, all-natural oral herbal supplement that addresses age-related hair loss in humans by promoting healthy hair growth, skin complexion, energy and vitality.* Clinical cases indicate that, if used uninterruptedly and in sufficient amounts, PriaPlex can arrest abnormal hair loss in approximately 85% of subjects within four to eight weeks.* New hairs generally begin to appear on the scalp within three to six months, and original hair color has been reported to emerge among white hairs after six months.*